Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.

@article{Sang2015MultifunctionalSH,
  title={Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.},
  author={Zhipei Sang and Yan Li and Xiaoming Qiang and Ganyuan Xiao and Qiang Liu and Zhenghuai Tan and Yong Deng},
  journal={Bioorganic & medicinal chemistry},
  year={2015},
  volume={23 4},
  pages={668-80}
}
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized based on the multitarget-directed ligand strategy. Their acetylcholinesterase and butyrylcholinesterase inhibitory activities, antioxidant activities, metal-chelating properties and neuroprotective effects against hydrogen peroxide induced PC12 cell injury were evaluated in vitro. The results showed that most of the synthetic compounds… CONTINUE READING

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