Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.

@article{Valckenborgh2004MultifunctionalRO,
  title={Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.},
  author={Els Van Valckenborgh and Peter Ian Croucher and Hendrik De Raeve and Chris Carron and Evy de Leenheer and Sylvia Blacher and Laetitia Devy and Agn{\'e}s No{\"e}l and Elke De Bruyne and Kewal Asosingh and Ivan Van Riet and Ben van Camp and Karin Vanderkerken},
  journal={The American journal of pathology},
  year={2004},
  volume={165 3},
  pages={869-78}
}
Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the proliferation of malignant plasma cells in the bone marrow, increased angiogenesis, and the development of osteolytic bone disease. The role of MMPs in the development of multiple myeloma is poorly understood. Using SC-964, a potent inhibitor of several MMPs… CONTINUE READING

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