Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer

@article{Kim2013MultifunctionalPC,
  title={Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer},
  author={Hyun Jin Kim and Takehiko Ishii and Meng Zheng and Sumiyo Watanabe and Kazuko Toh and Yu Matsumoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka},
  journal={Drug Delivery and Translational Research},
  year={2013},
  volume={4},
  pages={50-60}
}
For systemic small interfering RNA (siRNA) delivery to tumor mass, a multifunctional polyion complex micelle was constructed with a block copolymer bearing a targeting ligand and a micelle-stabilizing moiety as well as an endosome-disrupting cationic unit. The block copolymer was comprised of poly(ethylene glycol) (PEG) and a polyaspartamide derivative with flanking cationic tetraethylenepentamine (TEP) moiety (PAsp(TEP)), in which the distal ends of PEG and PAsp(TEP) were further installed… CONTINUE READING
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