Multifunctional poly(ethylene glycol) semi-interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting.

@article{Drumheller1994MultifunctionalPG,
  title={Multifunctional poly(ethylene glycol) semi-interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting.},
  author={Paul D. Drumheller and Donald L. Elbert and Jeffrey A Hubbell},
  journal={Biotechnology and bioengineering},
  year={1994},
  volume={43 8},
  pages={
          772-80
        }
}
Novel artificial extracellular matrices were synthesized in the form of semi-interpenetrating polymer networks containing copolymers of poly(ethylene glycol) and acrylic acid (PEG-co-AA) grafted with synthetic bioadhesive peptides onto exposed carboxylic acid moieties. These substrates were very resistant to cell adhesion, but when they were grafted with adhesive peptides they were highly biospecific in their ability to support cell adhesion. Extensive preadsorption of adhesive proteins or… CONTINUE READING

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