Multifunctional magnetic nanoparticles for enhanced intracellular drug transport.

@article{Tudisco2015MultifunctionalMN,
  title={Multifunctional magnetic nanoparticles for enhanced intracellular drug transport.},
  author={C Tudisco and Maria Teresa Cambria and Fulvia Sinatra and Federico Bertani and Anna Alba and Antonino E. Giuffrida and Salvatore Saccone and Elvira Fantechi and Claudia Innocenti and Claudio Sangregorio and Enrico Dalcanale and Guglielmo Guido Condorelli},
  journal={Journal of materials chemistry. B},
  year={2015},
  volume={3 20},
  pages={
          4134-4145
        }
}
In this paper we report the synthesis and characterization of biocompatible multi-functional magnetic nanoparticles (MNPs) able to enhance the intracellular transport of N-methylated drugs. The Fe3O4 magnetic core was first functionalized with a mixed monolayer consisting of two different phosphonic acids having terminal acetylenic and amino groups, which provide an active platform for further functionalization with organic molecules. Then, a tetraphosphonate cavitand receptor (Tiiii) bearing… 
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The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial IONP@GA composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries.
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The prepared water-soluble Fe3O4-CDs hybrid NPs have a dual modal imaging ability for both magnetic resonance imaging (MRI) and fluorescence imaging.
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In vitro studies show the multifunctional nanocarrier feasibility and advantage for remote-controlled drug release systems for stimuli-responsive controlled drug delivery systems.
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