Multifunctional in vivo vascular imaging using near-infrared II fluorescence

@article{Hong2012MultifunctionalIV,
  title={Multifunctional in vivo vascular imaging using near-infrared II fluorescence},
  author={Guosong Hong and Jerry C Lee and Joshua Tucker Robinson and Uwe Raaz and Liming Xie and Ngan F Huang and John P Cooke and Hongjie Dai},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1841-1846}
}
In vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both high spatial (∼30 μm) and temporal (<200 ms per frame) resolution for small-vessel imaging are achieved at 1–3 mm deep in the hind limb owing to the beneficial NIR-II optical window that affords deep anatomical penetration and low scattering. This spatial resolution is unattainable by traditional NIR imaging… CONTINUE READING
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