Multifunctional aspects of allopregnanolone in stress and related disorders

  title={Multifunctional aspects of allopregnanolone in stress and related disorders},
  author={Anjana Bali and A. Jaggi},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • Anjana Bali, A. Jaggi
  • Published 2014
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived neurosteroid in the central nervous system and is synthesized from progesterone by steroidogenic enzymes, 5α-reductase (the rate-limiting enzyme) and 3α-hydroxysteroid dehydrogenase. The pathophysiological role of allopregnanolone in neuropsychiatric disorders has been highlighted in several investigations. The changes in neuroactive steroid levels are detected in stress and stress-related disorders including anxiety… CONTINUE READING
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