Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration.

@article{Bansal2008MultifunctionalTC,
  title={Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration.},
  author={Anju Bansal and Bethany K. Jackson and Kim West and Shixia Wang and Shan Da Nan Lu and Jeffrey S. Kennedy and Paul A Goepfert},
  journal={Journal of virology},
  year={2008},
  volume={82 13},
  pages={
          6458-69
        }
}
A phase I clinical vaccine study of a human immunodeficiency virus type 1 (HIV-1) vaccine regimen comprising a DNA prime formulation (5-valent env and monovalent gag) followed by a 5-valent Env protein boost for seronegative adults was previously shown to induce HIV-1-specific T cells and anti-Env antibodies capable of neutralizing cross-clade viral isolates. In light of these initial findings, we sought to more fully characterize the HIV-1-specific T cells by using polychromatic flow cytometry… CONTINUE READING

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T-CELL FUNCTIONALITY DEPENDS ON VACCINE ROUTE AND DOSE 6467 on Jne 27, 2017 by gest http/jvi.asm .rg/ D ow nladed fom Hudacik

A. D. Cristillo, S. Wang, +4 authors L. VOL
  • Virology
  • 2008

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