Multifunctional Envelope-Type Nano Device: Evolution from Nonselective to Active Targeting System.

@article{Hayashi2015MultifunctionalEN,
  title={Multifunctional Envelope-Type Nano Device: Evolution from Nonselective to Active Targeting System.},
  author={Yasuhiro Hayashi and Hiroto Hatakeyama and Kazuaki Kajimoto and Mamoru Hyodo and Hidetaka Akita and Hideyoshi Harashima},
  journal={Bioconjugate chemistry},
  year={2015},
  volume={26 7},
  pages={1266-76}
}
A paradigm shift has occurred in the field of drug delivery systems (DDS), one being intracellular targeting, and the other, active targeting. An important aspect of intracellular targeting involves delivering nucleic acids such as siRNA/pDNA rather than small molecular compounds, since the mechanism responsible for their entering a target cell is usually… CONTINUE READING