Multifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

@article{Poulose2016MultifunctionalCN,
  title={Multifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453},
  author={A. C. Poulose and S. Veeranarayanan and M. S. Mohamed and R. R. Aburto and T. Mitcham and R. Bouchard and P. Ajayan and Y. Sakamoto and T. Maekawa and D. S. Kumar},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2−XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided… Expand
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