Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling


It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent triggers for epithelial tumors. Mice carrying a mesenchymal… (More)
DOI: 10.1016/j.cell.2012.03.048


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