Multiflorumisides HK, stilbene glucosides isolated from Polygonum multiflorum and their in vitro PTP1B inhibitory activities.

  title={Multiflorumisides HK, stilbene glucosides isolated from Polygonum multiflorum and their in vitro PTP1B inhibitory activities.},
  author={Jianbo Yang and Fei Ye and Jin-Ying Tian and Yunfei Song and Huiying Gao and Yue Liu and Qi Wang and Ying Wang and Shuangcheng Ma and Xianlong Cheng and Feng Wei},
Transformation of Stilbene Glucosides From Reynoutria multiflora During Processing
The root of Reynoutria multiflora Thunb. Moldenke (RM, syn.: Polygonum multiflorum Thunb.) has been widely used in TCM clinical practice for centuries. The raw R. multiflora (RRM) should be processed
Role of stilbenes against insulin resistance: A review
In this review, efforts are made to elucidate cellular and subcellular mechanisms influenced by stilbenes including modulating insulin signaling cascade, correcting glucose transport pathways, lowering postprandial glucose levels, and protecting β‐cell damage and its effects on the hyperactive immune system and proinflammatory cytokines to attenuate IR.
Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants
It is suggested that Coreopsis tinctoria, Lithocarpus polystachyus, and Panax ginseng can be good candidates for developing herbal medicines or phytomedicines that target inhibition of hepatic glucose output as they can modulate the activity of PTP-1B, the expression of gluconeogenic enzymes, and the glycogen content.


Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Polygonum multiflorum.
This represents the first isolation of a phenylpropanoid substituted with a stilbene unit from the Polygonaceae family and the inhibition modes and binding mechanism of selected inhibitors were investigated using kinetic methods and molecular docking simulations.
Multiflorumisides A-G, Dimeric Stilbene Glucosides with Rare Coupling Patterns from the Roots of Polygonum multiflorum.
Putative biosynthetic pathways toward the dimers and their suppressive effects against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells are also discussed.
Polygonumosides A-D, stilbene derivatives from processed roots of Polygonum multiflorum.
Four new stilbene derivatives, polygonumosides A-D (1-4), were isolated from the processed roots of Polygonum multiflorum. Their structures were elucidated by spectroscopic analysis, including 1D and
Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and
Hepatoprotective phenolic glycosides from Gymnema tingens.
Six new phenolic diglycosides, named gymnetinosides A-F (1-6), were isolated from the ethanolic extract of Gymnema tingens and showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
Unusual Prenylated Stilbene Derivatives with PTP1B Inhibitory Activity from Artocarpus styracifolius.
Kinetic analysis and molecular docking simulations revealed mixed-type PTP1B inhibition for all compounds tested, suggesting that these compounds may have a potential to be further developed as agents for the management of type 2 diabetes mellitus.
Lipoxygenase inhibitory constituents from rhubarb
Results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.