Multifarious Functions of the Fragile X Mental Retardation Protein.

@article{Davis2017MultifariousFO,
  title={Multifarious Functions of the Fragile X Mental Retardation Protein.},
  author={Jenna Davis and Kendal Broadie},
  journal={Trends in genetics : TIG},
  year={2017},
  volume={33 10},
  pages={
          703-714
        }
}
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability. Canonically, FMRP functions as an mRNA-binding translation suppressor, but recent findings have enormously expanded its proposed roles. Although connections between burgeoning FMRP functions remain unknown, recent advances have extended… CONTINUE READING

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