Multifactorial screening design and analysis of SELDI-TOF ProteinChip array optimization experiments.

@article{Cordingley2003MultifactorialSD,
  title={Multifactorial screening design and analysis of SELDI-TOF ProteinChip array optimization experiments.},
  author={Hayley C. Cordingley and Susan L. Roberts and P Tooke and J R Armitage and Priscilla W. Lane and Wei Wu and S E Wildsmith},
  journal={BioTechniques},
  year={2003},
  volume={34 2},
  pages={
          364-5, 368-73
        }
}
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry is a powerful tool for rapidly generating protein expression data (peptide and protein profiles) from a large number of samples. However, as with any technology, it must be optimized and reproducible for one to have confidence in the results. Using a classical statistical method called the fractional factorial design of experiments, we assessed the effects of 11 different experimental factors. We also developed… CONTINUE READING

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