Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

@article{Jung2011MultifactorialOO,
  title={Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.},
  author={Jangwook P Jung and Jose V Moyano and Joel H. Collier},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2011},
  volume={3 3},
  pages={185-96}
}
Extracellular matrices (ECMs) are complex materials, containing at least dozens of different macromolecules that are assembled together, thus complicating their optimization towards applications in 3D cell culture or tissue engineering. The natural complexity of ECMs has limited cell-matrix investigations predominantly to experiments where only one matrix component is adjusted at a time, making it difficult to uncover interactions between different matrix components or to efficiently determine… CONTINUE READING

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