Multifactorial nature of hepatocellular carcinoma drug resistance: could plant polyphenols be helpful?

Abstract

Primary hepatocellular carcinoma (HCC) is a quite frequent tumor which results in high mortality and most often exhibits a poor response to present drug therapies. Clearly, a thorough understanding of the biological bases of this malignancy might suggest new strategies for its treatment. Here we examine the evidences that both "pharmacological" mechanisms… (More)

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