Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.

  title={Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.},
  author={Peter Haulund Gaede and Pernille Nygaard Vedel and Nicolai Larsen and Gunnar Vagn Hagemann Jensen and Hans-Henrik D. Parving and Oluf Pedersen},
  journal={The New England journal of medicine},
  volume={348 5},
BACKGROUND Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment on modifiable risk factors for cardiovascular disease in patients with type 2 diabetes and microalbuminuria. METHODS The primary end point of this open, parallel trial was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke… 

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