Multifactorial genetics: The use of molecular genetics in the improvement of agricultural populations

@article{Dekkers2002MultifactorialGT,
  title={Multifactorial genetics: The use of molecular genetics in the improvement of agricultural populations},
  author={Jack C. M. Dekkers and Fr{\'e}d{\'e}ric Hospital},
  journal={Nature Reviews Genetics},
  year={2002},
  volume={3},
  pages={22-32}
}
Substantial advances have been made in the genetic improvement of agriculturally important animal and plant populations through artificial selection on quantitative traits. Most of this selection has been on the basis of observable phenotype, without knowledge of the genetic architecture of the selected characteristics. However, continuing molecular genetic analysis of traits in animal and plant populations is leading to a better understanding of quantitative trait genetics. The genes and… 
Principles of QTL Mapping
To date, most genetic progress for quantitative traits in livestock has been made by selection on phenotype or on estimates of breeding values (EBV) derived from phenotype, without knowledge of the
Marker assisted selection in crop plants
TLDR
Recent advances in genotyping technologies together with comparative and functional genomic approaches are providing useful tools for the selection of genotypes with superior agronomical performancies.
Mapping QTL for agronomic traits in breeding populations
  • T. Würschum
  • Biology, Medicine
    Theoretical and Applied Genetics
  • 2012
TLDR
This review characterizes the germplasm from breeding populations available for QTL detection, provides a classification of the different QTL mapping approaches that are available, and highlights important considerations concerning study design and biometrical models suitable forQTL analysis.
Use of molecular markers for the development of new cultivars and the evaluation of genetic diversity
TLDR
It is reviewed here how this information on the determinism of trait variation and the organisation of genetic diversity within plant species of agricultural interest can be used to increase the efficiency of plant breeding programs, considering both theoretical analyses and recent experimental data.
ANIMAL BREEDING IN THE GENOMICS ERA
TLDR
Advances in the identification of Quantitative Trait Loci and genes that influence agronomically important traits and the use of this novel information in socalled marker assisted selection (MAS) are discussed.
Molecular markers in population genetics and breeding of cultivated plants
Information on the use of molecular and traditional genetic markers in population genetics and breeding of agricultural plants is presented. An assessment of the level of diversity in populations is
Mapping genes for complex traits in domestic animals and their use in breeding programmes
TLDR
This work uses genome-wide SNP panels as markers and statistical methods that capture the effects of large numbers of SNPs simultaneously to double the rate of genetic improvement per year in many livestock systems.
Application of molecular markers in farm animal improvement: prospects and challenges.
TLDR
The overview of the applications of molecular markers in the areas of genetic diversity conservation, identification of disease carriers, parentage determination, marker-assisted selection, transgenesis, sex-determination, and the enumeration of some challenges to the application in the developing countries, especially Nigeria form the crux of this paper.
Does genomic selection have a future in plant breeding?
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 75 REFERENCES
Marker-assisted selection: new tools and strategies
Genetic dissection of phenotypic diversity in farm animals
TLDR
Genome research in farm animals will add to the basic understanding of the genetic control of these traits and the results will be applied in breeding programmes to reduce the incidence of disease and to improve product quality and production efficiency.
Mapping quantitative trait loci in plants: uses and caveats for evolutionary biology
Gregor Mendel was either clever or lucky enough to study traits of simple inheritance in his pea plants; however, many plant characters of interest to modern geneticists are decidedly complex.
Marker-assisted selection in autogamous RIL populations: a simulation study
TLDR
Assessment of the effectiveness of marker-assisted selection compared to phenotypic selection showed that the application of MAS in autogamous crops, with the objective of obtaining transgressive genotypes, can improve selection results when compared to conventional selection procedures.
Quantitative genetics, genomics and plant breeding
Part I Genomics, quantitative trait loci, and tissue culture: why quantitative geneticists should care about bioinformatics use of molecular markers in plant breeding - drought tolerance improvements
RFLP Mapping in Plant Breeding: New Tools for an Old Science
TLDR
RFLP linkage maps provide a more direct method for selecting desirable genes via their linkage to easily detectable RFLP markers and may make it possible to clone genes whose products are unknown, such as genes for disease resistance or stress tolerance.
Efficiency of marker-assisted selection in the improvement of quantitative traits.
TLDR
This work derives selection indices that maximize the rate of improvement in quantitative characters under different schemes of MAS combining information on molecular genetic polymorphisms (marker loci) with data on phenotypic variation among individuals (and their relatives).
The impact of genetic markers on selection.
TLDR
Genetic marker technologies, such as marker-assisted selection, parentage identification, and gene introgression can be applied to livestock selection programs and a pattern of annual benefits and costs can be predicted using gene flows that can be evaluated by conventional economic analysis.
On the efficiency of marker-assisted introgression
TLDR
It was found that most of the genetic lag occurs in the latter stages of an introgression programme, when males and females which are heterozygous for the allele to be introgressed are mated to produce homozygous individuals.
Optimal positioning of markers to control genetic background in marker-assisted backcrossing.
TLDR
This paper describes how one can compute an optimal positioning of markers resulting in a maximization of the expected proportion of recipient genome that allows for the final efficiency of background selection in backcross programs.
...
1
2
3
4
5
...