Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

@article{Lakhani1998MultifactorialAO,
  title={Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.},
  author={Sunil R Lakhani and Jocelyne D. Jacquemier and John P Sloane and Barry Gusterson and Thomas J. Anderson and Marc Joan Van de Vijver and Linda M. Farid and Deon J Venter and Antonios Antoniou and Amy Storfer-Isser and Elizabeth H. Smyth and Catherine M. Steel and Neva Haites and Rodney J. Scott and David E. Goldgar and Susan L. Neuhausen and Peter Augustine Daly and Wilma J Ormiston and Ross McManus and Siegfried Scherneck and Bruce A. J. Ponder and Deborah Ford and Julian Peto and Dominique Stoppa-Lyonnet and Y. J. Bignon and Jeffery P. Struewing and N. K. Spurr and D Timothy Bishop and Jan G. M. Klijn and Peter Devilee and Cees J. Cornelisse and Christine Lasset and Gilbert M. Lenoir and Rosa Bj{\"o}rk Barkardottir and Valgardur Egilsson and Ute Hamann and Jenny Chang-Claude and Hagay Sobol and B{\'e}atrice Weber and Michael R. Stratton and Douglas F. Easton},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 15},
  pages={1138-45}
}
BACKGROUND We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors. METHODS Specimens of tumor tissue (5-microm-thick sections) were examined… CONTINUE READING
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