Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions

@article{Hahn2003MultifactorDR,
  title={Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions},
  author={Lance W. Hahn and Marylyn DeRiggi Ritchie and Jason H. Moore},
  journal={Bioinformatics},
  year={2003},
  volume={19 3},
  pages={
          376-82
        }
}
MOTIVATION Polymorphisms in human genes are being described in remarkable numbers. Determining which polymorphisms and which environmental factors are associated with common, complex diseases has become a daunting task. This is partly because the effect of any single genetic variation will likely be dependent on other genetic variations (gene-gene interaction or epistasis) and environmental factors (gene-environment interaction). Detecting and characterizing interactions among multiple factors… 

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