Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.

  title={Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.},
  author={Marylyn DeRiggi Ritchie and Lance W. Hahn and Nady Roodi and L. R. Bailey and William D. Dupont and Fritz F Parl and J. H. Moore},
  journal={American journal of human genetics},
  volume={69 1},
One of the greatest challenges facing human geneticists is the identification and characterization of susceptibility genes for common complex multifactorial human diseases. This challenge is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes and with environmental exposures. We introduce multifactor-dimensionality reduction (MDR) as a method for reducing the dimensionality of… 

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