Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.

@article{Ritchie2005MultifactorDR,
  title={Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.},
  author={Marylyn DeRiggi Ritchie and Alison A. Motsinger},
  journal={Pharmacogenomics},
  year={2005},
  volume={6 8},
  pages={
          823-34
        }
}
In the quest for discovering disease susceptibility genes, the reality of gene-gene and gene-environment interactions creates difficult challenges for many current statistical approaches. In an attempt to overcome limitations with current disease gene detection methods, the multifactor dimensionality reduction (MDR) approach was previously developed. In brief, MDR is a method that reduces the dimensionality of multilocus information to identify polymorphisms associated with an increased risk of… 
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