Multifaceted roles of cyclooxygenase-2 in lung cancer.

  title={Multifaceted roles of cyclooxygenase-2 in lung cancer.},
  author={Karen L Riedl and Kostyantyn Krysan and Mehis P{\~o}ld and Harnisha Dalwadi and Nathalie Heuz{\'e}-Vourc'h and Mariam Dohadwala and Ming Liu and Xiaoyan Cui and Robert J. Figlin and Jenny T. Mao and Robert Strieter and Sherven P Sharma and Steven Dubinett},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={7 3},
Lung cancer is the leading cause of cancer death in the United States. Although the low 5-year survival rate (under 15%) has changed minimally in the last 25 years, new agents and combinations of agents that target tumor proliferation, invasion, and survival may lead to improvement in patient outcomes. There is evidence that cyclooxygenase-2 (COX-2) is overexpressed in lung cancer and promotes tumor proliferation, invasion, angiogenesis, and resistance to apoptosis. COX-2 inhibitors have been… CONTINUE READING

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