Multifaceted roles of STIM proteins

Stromal interaction molecules (STIM1 and STIM2) are critical components of store-operated calcium entry. Sensing depletion of endoplasmic reticulum (ER) Ca2+ stores, STIM couples with plasma membrane Orai channels, resulting in the influx of Ca2+ across the PM into the cytosol. Although best recognized for their primary role as ER Ca2+ sensors, increasing… CONTINUE READING