Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs

@article{Sikri2018MultifacetedRB,
  title={Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs},
  author={K. Sikri and P. Duggal and Chanchal Kumar and S. Batra and A. Vashist and Ashima Bhaskar and Kriti Tripathi and Tavpritesh Sethi and Amit Singh and J. Tyagi},
  journal={Redox Biology},
  year={2018},
  volume={15},
  pages={452 - 466}
}
Bacterial dormancy is a major impediment to the eradication of tuberculosis (TB), because currently used drugs primarily target actively replicating bacteria. Therefore, decoding of the critical survival pathways in dormant tubercle bacilli is a research priority to formulate new approaches for killing these bacteria. Employing a network-based gene expression analysis approach, we demonstrate that redox active vitamin C (vit C) triggers a multifaceted and robust adaptation response in… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
Mycobacterium tuberculosis: success through dormancy.
  • 497
  • Highly Influential
  • PDF
Redox homeostasis in mycobacteria: the key to tuberculosis control?
  • 146
  • PDF
Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity
  • 195
  • PDF
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
  • 154
  • PDF
Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction
  • 186
  • Highly Influential
  • PDF
A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
  • 328
  • Highly Influential
  • PDF
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
  • 1,194
  • PDF
...
1
2
3
4
5
...