Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ.

@article{Wojtaszek2012MultifacetedRO,
  title={Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ.},
  author={Jessica L. Wojtaszek and Jiangxin Liu and Sanjay D'Souza and Su Xing Wang and Yaohua Xue and Graham C Walker and Pei Zhou},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 31},
  pages={26400-8}
}
Translesion synthesis is a fundamental biological process that enables DNA replication across lesion sites to ensure timely duplication of genetic information at the cost of replication fidelity, and it is implicated in development of cancer drug resistance after chemotherapy. The eukaryotic Y-family polymerase Rev1 is an essential scaffolding protein in translesion synthesis. Its C-terminal domain (CTD), which interacts with translesion polymerase ζ through the Rev7 subunit and with… CONTINUE READING