Multifaceted genomic risk for brain function in schizophrenia

  title={Multifaceted genomic risk for brain function in schizophrenia},
  author={Vince D. Calhoun and Godfrey D. Pearlson and Stefan Ehrlich and Jessica A. Turner and Beng-Choon Ho and Thomas H. Wassink and Andrew Michael and Jingyu Liu},
Recently, deriving candidate endophenotypes from brain imaging data has become a valuable approach to study genetic influences on schizophrenia (SZ), whose pathophysiology remains unclear. In this work we utilized a multivariate approach, parallel independent component analysis, to identify genomic risk components associated with brain function abnormalities in SZ. 5157 candidate single nucleotide polymorphisms (SNPs) were derived from genome-wide array based on their possible connections with… CONTINUE READING


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