Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation

@inproceedings{Maren2010MultifacetedEO,
  title={Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation},
  author={Wendy W C van Maren and Stefan Nierkens and Liza W J Toonen and Judith M. Bolscher and Roger P. M. Sutmuller and Gosse J Adema},
  booktitle={BMC Immunology},
  year={2010}
}
Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam3CysSK4, directly stimulated Tregs to expand and temporarily abrogate their suppressive capabilities. In this study, we evaluate the effect of Pam3CysSK4 and Legionella pneumophila, a… CONTINUE READING
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