Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.

@article{Giaccone1992MultidrugSP,
  title={Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.},
  author={Guiseppe Giaccone and Adi F. Gazdar and Heike Beck and Franco Zunino and Giovanni Capranico},
  journal={Cancer research},
  year={1992},
  volume={52 7},
  pages={1666-74}
}
Patterns of drug sensitivities in relation to topoisomerase II gene expression and activity were studied in eight human lung cancer cell lines not selected in vitro for drug resistance. The cytotoxicities of doxorubicin, etoposide, teniposide, cisplatin, camptothecin, and 5-fluorouracil were measured and, remarkably, these unselected cell lines were shown to have a common pattern of multidrug sensitivity, i.e., a multidrug sensitivity phenotype. In fact, drug sensitivities were significantly… CONTINUE READING