Multidrug resistant tuberculosis

@article{Millard2015MultidrugRT,
  title={Multidrug resistant tuberculosis},
  author={James Millard and C{\'e}sar Ugarte-Gil and David A. J. Moore},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={350}
}
#### The bottom line Tuberculosis remains a major cause of morbidity and mortality globally, with an estimated nine million people developing the disease and 1.5 million deaths in 2013; equating to 4100 deaths a day.1 Nevertheless, considerable gains have been made in international tuberculosis control; incidence rates are decreasing (albeit slowly) and mortality has been reduced by 45% worldwide. The advent of multidrug resistant tuberculosis threatens this progress. In this review we detail… 

Recent therapeutic approaches for the management of tuberculosis: Challenges and opportunities.

Predictors of Time to Sputum Culture Conversion Among Drug-Resistant Tuberculosis Patients in Oromia Region Hospitals, Ethiopia

TLDR
Chest radiographic findings such as massive effusion, abnormalities without cavitations, and uninterpreted findings were found to be predictors of time to sputum culture conversion among drug-resistant tuberculosis patients.

Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter’s Specialized Hospital

TLDR
The MDR-TB patients with weight gain, khat and alcohol consumption, clinical complication of pneumothorax and pneumonia, extrapulmonary TB, and history of anti-TB drug consumption as well as those who lived in rural areas had a shorter survival time, compared to others.

PHARMACOKINETICS OF INH AND PZA IN MDR-TB: A REVIEW

  • S. RamyaS. Shanmugam
  • Medicine, Biology
    International Journal of Pharmaceutical and Biological Science Archive
  • 2019
TLDR
The complications of drug resistance in TB elevates the some of the risk factors like inadequate treatment compliance, noncompliance of the patients to the treatment, and pharmacokinetic processes referred to as ADME.

Predictors and Trends of MDR/RR-TB in Shenzhen China: A Retrospective 2012–2020 Period Analysis

TLDR
The authors' multivariate analysis showed that age younger than 30 years, housework service/unemployment, local residency, and previous TB treatment were all predictors of MDR/RR-TB rates, which should be considered when developing targeted MDR-TB control strategies.

Targeting the Serine Pathway: A Promising Approach against Tuberculosis? †

TLDR
An overview of current treatment options against tuberculosis is given and a promising approach of discovering new effective drugs is pointed out.

References

SHOWING 1-10 OF 25 REFERENCES

Multidrug-resistant tuberculosis: epidemiology, risk factors and case finding.

  • J. Caminero
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2010
TLDR
The recognition of factors leading to the epidemic in some regions and the identification of populations at risk will assist in focusing case-finding efforts, and patients previously treated for TB and the other risk factors analysed in this article should be prioritised in case finding.

Risk factors for multidrug resistant tuberculosis in Europe: a systematic review

TLDR
Previous treatment was the strongest determinant of MDR-TB in Europe, and the risk of MDA in foreign born people needs to be re-evaluated, taking into account any previous treatment.

Programmatic management of multidrug-resistant tuberculosis: models from three countries.

  • J. FurinJ. Bayona S. Shin
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2011
TLDR
This study describes MDR-TB treatment models in three countries--Peru, Russia and Lesotho-- using qualitative data collected over a 13-year period to reveal six overarching themes common to all three programs.

Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis.

TLDR
Serial regimen formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with first-line treatment, including a relapse-free cure among 206 patients.

Turning off the spigot: reducing drug-resistant tuberculosis transmission in resource-limited settings.

  • E. NardellA. Dharmadhikari
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2010
TLDR
A simple triage and separation strategy is presented, it is pointed out that separation is intimately linked to the design and engineering of clinical space and the pros and cons of natural ventilation, simple mechanical ventilation systems, germicidal ultraviolet air disinfection, fit-tested respirators on health care workers and short-term use of masks on patients before treatment is initiated.

Microscopic-observation drug-susceptibility assay for the diagnosis of TB.

TLDR
A single MODS culture of a sputum sample offers more rapid and sensitive detection of tuberculosis and multidrug-resistant tuberculosis than the existing gold-standard methods used.

Mixed Mycobacterium tuberculosis Complex Infections and False-Negative Results for Rifampin Resistance by GeneXpert MTB/RIF Are Associated with Poor Clinical Outcomes

TLDR
The Xpert assay has an increased false-negative rate for detecting rifampin resistance with mixed MTBC infections and in hyperendemic settings where mixed infections are common, the Xpert results might need further confirmation.