Multidrug-resistant hepatitis B virus resulting from sequential monotherapy with lamivudine, adefovir, and entecavir: clonal evolution during lamivudine plus adefovir therapy.

@article{Kim2013MultidrugresistantHB,
  title={Multidrug-resistant hepatitis B virus resulting from sequential monotherapy with lamivudine, adefovir, and entecavir: clonal evolution during lamivudine plus adefovir therapy.},
  author={Soon Sun Kim and Sung Won Cho and soo-ok kim and Sun Pyo Hong and Jae Youn Cheong},
  journal={Journal of medical virology},
  year={2013},
  volume={85 1},
  pages={
          55-64
        }
}
Whether multidrug-resistant (MDR) hepatitis B virus (HBV) harbors mutations co-located in the same HBV clones that confer reduced sensitivity to antiviral therapy remains uncertain. This study investigated the evolution of MDR HBV strains developed from sequential monotherapy with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) during LAM plus ADV salvage therapy. Sera were obtained from six patients who had developed sequential resistance to LAM, ADV, and ETV before and during LAM plus… CONTINUE READING
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Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.

  • Liver international : official journal of the International Association for the Study of the Liver
  • 2015
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Detection and analysis of resistance mutations of hepatitis B virus.

  • International journal of clinical and experimental medicine
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