Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy.

@article{Zavascki2010MultidrugresistantPA,
  title={Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy.},
  author={Alexandre Prehn Zavascki and Cecilia Helena Vieira Franco Godoy Carvalh{\~a}es and Renata Cristina Pic{\~a}o and Ana Cristina Gales},
  journal={Expert review of anti-infective therapy},
  year={2010},
  volume={8 1},
  pages={71-93}
}
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to virtually any antimicrobial agent. An increasing prevalence of infections caused by multidrug-resistant (MDR) isolates has been reported in many countries. The resistance mechanisms of P. aeruginosa and A. baumannii include the production of beta-lactamases, efflux pumps, and target-site or outer membrane modifications… CONTINUE READING

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