Multidrug resistance. Clinical opportunities in diagnosis and circumvention.

  title={Multidrug resistance. Clinical opportunities in diagnosis and circumvention.},
  author={Helen Shuk-ying Chan and Gerrit E Deboer and Paul Scott Thorner and George Haddad and Brenda L. Gallie and Victor Ling},
  journal={Hematology/oncology clinics of North America},
  volume={8 2},
Increased P-glycoprotein expression has been shown to be the molecular cause of multidrug resistance in tumor cell lines. Sensitive immunohistochemical and molecular biologic techniques have been developed to detect P-glycoprotein/mdr1 mRNA expression in clinical samples of tumors. We have reviewed the tools now available for assessment of P-glycoprotein expression in the clinic, the current evidence for a relevant role of the protein in mediation of resistance to chemotherapy, and one strategy… CONTINUE READING


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