Multidrug resistance transporters and modulation.

  title={Multidrug resistance transporters and modulation.},
  author={Benjamin R. Tan and David R. Piwnica-Worms and Lee Ratner},
  journal={Current opinion in oncology},
  volume={12 5},
Multidrug resistance (MDR), whereby tumor cells simultaneously possess intrinsic or acquired cross-resistance to diverse chemotherapeutic agents, hampers the effective treatment of cancer. Molecular investigations in MDR resulted in the isolation and characterization of genes coding for several proteins associated with MDR, including P-glycoprotein (P-gp), the multidrug resistance associated protein (MRP1), the lung resistance protein (LRP), and, more recently, the breast cancer resistance… CONTINUE READING