Multidrug resistance reversal in human gastric carcinoma cells by neferine.

  title={Multidrug resistance reversal in human gastric carcinoma cells by neferine.},
  author={Jianguo Cao and Xiao-Qing Tang and Shu-Hong Shi},
  journal={World journal of gastroenterology},
  volume={10 20},
AIM To investigate the reversal effect of neferine on multidrug resistance in human gastric carcinoma cell line. METHODS Cells of a human gastric cancer cells line, SGC7901, and its vincristine (VCR) -resistant variant, SGC7901/VCR, were cultivated with or without neferine and/or VCR. The cytotoxic effect of VCR was evaluated by the MTT assay. Cell apoptosis induced by VCR was determined by flow cytometry (FCM). The expression of P-glycoprotein (P-gp) and a multidrug-resistance-associated… CONTINUE READING


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