Multidrug resistance proteins expression in glioma patients with epilepsy

  title={Multidrug resistance proteins expression in glioma patients with epilepsy},
  author={Chiara Calatozzolo and Bianca Pollo and Andrea Botturi and Loredana Dinapoli and Mariantonia A. Carosi and Andrea Salmaggi and Marta Maschio},
  journal={Journal of Neuro-Oncology},
Epilepsy occurs in glioma, especially in low-grade glioma (LGG), but also in glioblastoma (GBM). In about 20 % of patients pharmacological treatment with anti-epileptic drugs (AEDs) fails. Refractory epilepsy is a multifactorial phenomenon not yet completely understood. The multidrug resistance phenotype was initially associated to P-glycoprotein (Pgp), an ATP-dependent transporter belonging to the same superfamily of multidrug resistance-associated proteins (MRPs). Glutathione-S-transferase… CONTINUE READING
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