Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione.


The human multidrug resistance protein (MRP1) confers resistance of cells to a number of different cytostatic drugs and functions as an export pump for glutathione S-conjugates, glucuronides and other amphiphilic anions. The present study details for the first time MRP1-mediated ATP-dependent transport of various glutathione S-conjugates of the bifunctional… (More)
DOI: 10.1038/bjc.1998.34


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