Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.

@article{Wijnholds2000MultidrugresistanceP5,
  title={Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.},
  author={Jan Wijnholds and C A Mol and Liesbeth van Deemter and Marcel de Haas and George L. Scheffer and Frank Baas and Jos H. Beijnen and Rik J. Scheper and Sigrid Hatse and Erik De Clercq and Jan Balzarini and Piet Borst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 13},
  pages={
          7476-81
        }
}
  • J. Wijnholds, C. Mol, +9 authors P. Borst
  • Published 20 June 2000
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), can mediate the cellular extrusion of xenobiotics and (anticancer) drugs from normal and tumor cells. The MRP subfamily consists of at least six members, and here we report the functional characterization of human MRP5. We found resistance against the thiopurine anticancer drugs, 6-mercaptopurine (6-MP) and thioguanine… Expand
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  • D. Keppler
  • Biology, Medicine
  • Handbook of experimental pharmacology
  • 2011
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The role of MRP subfamily members in pathophysiology may be illustrated by the MRP-mediated release of proinflammatory and immunomodulatory mediators such as leukotrienes and prostanoids. Expand
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
  • G. Reid, P. Wielinga, +5 authors P. Borst
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
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Investigation of the interaction between prostaglandins and members of the ATP-binding cassette (ABC) transporter ABCC [multidrug resistance protein (MRP)] family of membrane export pumps suggests that MRP4 can release prostaglandsins from cells, and that some nonsteroidal antiinflammatory drugs might also act by inhibiting this release. Expand
The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides*
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Tissue distribution and subcellular localization of MRP4 and MRP5 specifically in smooth muscle cells, platelet-dense granules, and nervous cells, point not only to a possible function of these transporters as exporters in cellular defense, but also to a physiological function in signaling processes. Expand
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