Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.

  title={Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.},
  author={Jan Wijnholds and Elizabeth C. M. DeLange and George L. Scheffer and D J van den Berg and C A Mol and Martin A. van der Valk and Alfred H. Schinkel and Rik J. Scheper and D. D. Breimer and Piet Borst},
  journal={The Journal of clinical investigation},
  volume={105 3},
Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain xenobiotics. We previously showed that Mrp1 protects against cytotoxic drugs at the testis-blood barrier, the oral epithelium, and the kidney urinary collecting duct tubules. Here, we generated Mrp1/Mdr1a/Mdr1b triple-knockout (TKO) mice, and used them together with Mdr1a/Mdr1b double-knockout (DKO) mice to study the contribution of Mrp1 to the tissue… 

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