Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

@article{Lincke1990MultidrugRP,
  title={Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.},
  author={Carsten R. Lincke and Alexander M van der Bliek and Gerrit J Schuurhuis and T van der Velde-Koerts and Jaap Jan J. Smit and Piet Borst},
  journal={Cancer research},
  year={1990},
  volume={50 6},
  pages={1779-85}
}
We have transfected a eukaryotic expression vector containing a mdr1 complementary DNA isolated from normal human liver into human BRO melanoma cells to study the drug-resistant phenotype produced by the exclusive overexpression of normal human mdr1 P-glycoprotein. The drug resistance pattern of mdr1-transfected clones includes relatively high resistance to gramicidin D (about 300-fold), vincristine (about 100-fold), and actinomycin D (about 100-fold) and a lower degree of resistance to… CONTINUE READING

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