Multidrug resistance gene (P-glycoprotein) expression in the human fetus.

  title={Multidrug resistance gene (P-glycoprotein) expression in the human fetus.},
  author={Coenraad K van Kalken and Guiseppe Giaccone and Paul D. L. P. M. van der Valk and Catharina M. Kuiper and M M Hadisaputro and S A Bosma and Rik J. Scheper and Chris J L M Meijer and Herbert M. Pinedo},
  journal={The American journal of pathology},
  volume={141 5},
P-glycoprotein, a transmembrane protein associated with multidrug resistance in cancer cells, is also expressed in normal tissues. To get more insight into the physiologic role of mdr1/P-glycoprotein, we investigated its expression in human fetal tissues after 7 to 38 weeks of gestation by an immunohistochemical technique, using three different monoclonal antibodies, and by a sensitive RNAse protection assay. Expression of mdr1-mRNA could already be demonstrated in the embryonal phase of human… CONTINUE READING
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