Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.

@article{Hu2003MultidrugRC,
  title={Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.},
  author={Yan Ping Hu and Bushra Haq and Kermit L. Carraway and Niramol Savaraj and Theodore J. Lampidis},
  journal={Biochemical pharmacology},
  year={2003},
  volume={65 9},
  pages={1419-25}
}
Due to the size, glycosylation, and location in the plasma membrane of the sialomucin complex Muc4, which has been implicated in ErbB2 signaling, in the repression of apoptosis and cell adhesion, and in tumor metastasis, studies were initiated to determine whether its presence could influence cell sensitivity to anticancer drugs. Growth inhibition assays using melanoma cell lines that either express the glycoprotein (Muc4(+)) or do not (Muc4(-)) showed that Muc4 renders cells resistant to taxol… CONTINUE READING

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