Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.

@article{Hasegawa2007MultidrugRP,
  title={Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.},
  author={Maki Hasegawa and Hiroyuki Kusuhara and Masashi Adachi and John D. Schuetz and Kenji Takeuchi and Yuichi Sugiyama},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 1},
  pages={37-45}
}
The role of ATP-binding cassette transporters in the urinary excretion of diuretics was investigated. Significant ATP-dependent uptake of hydrochlorothiazide (HCT) and furosemide was observed in membrane vesicles that expressed multidrug resistance-associated protein 4 (MRP4) and breast cancer resistance protein (BCRP). Unlike taurocholate uptake, S-methylglutathione had no effect on the ATP-dependent uptake of both compounds by MRP4. The functional importance of MRP4 and BCRP in the urinary… CONTINUE READING