Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.

@article{Mallants2005MultidrugRP,
  title={Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.},
  author={Roel Mallants and K Van Oosterwyck and Luc Van Vaeck and R. F. Mols and Erick De Clercq and Patrick R Augustijns},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2005},
  volume={35 10-11},
  pages={1055-66}
}
The role of multidrug resistance-associated protein 2 (MRP2) on the intestinal disposition and hepatobiliary elimination of tenofovir disoproxil fumarate (DF) and its metabolites [tenofovir (mono)ester and tenofovir] was studied in the Caco-2 system, Ussing chambers and rat in-situ efflux experiments. In the Caco-2 model and Ussing chambers, no statistically significant differences in transport could be observed when the MRP inhibitor probenecid was included. In Ussing chambers, transport was… CONTINUE READING