Multidrug resistance-associated protein 1 (MRP1) expression in neuroblastoma cell lines and primary tumors.

@article{Goto2000MultidrugRP,
  title={Multidrug resistance-associated protein 1 (MRP1) expression in neuroblastoma cell lines and primary tumors.},
  author={Hiroshi Goto and Nino Keshelava and Katherine K. Matthay and John Nicholas Lukens and Robert B. Gerbing and Daniel O. Stram and Robert C. Seeger and C Patrick Reynolds},
  journal={Medical and pediatric oncology},
  year={2000},
  volume={35 6},
  pages={619-22}
}
BACKGROUND AND PROCEDURE MRP1 expression by neuroblastomas was evaluated by Northern blot analysis in 21 cell lines and 90 primary untreated tumors. Cytotoxicity assay in cell lines was performed for five anticancer drugs used in treating neuroblastoma. RESULTS MRP1 expression did not correlate with drug resistance or with MYCN RNA expression in cell lines. MRP1 expression was higher in drug-sensitive cell lines established after chemotherapy relative to cell lines at diagnosis, but highly… CONTINUE READING

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