Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction.

@article{Sun2004MultidrugRP,
  title={Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction.},
  author={Jin Sun and Zhong-gui He and Gang Cheng and Shujun Wang and Xiu-hua Hao and Mei-Juan Zou},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2004},
  volume={10 1},
  pages={RA5-14}
}
This article reviews recent advances in our understanding of the structure, drug interaction mechanism, and substrate molecular requirements of P-glycoprotein (P-gp) and its emerging crucial role in drug disposition and the modulation of drug interaction. In view of its wide localization in normal tissues, the broad variety of structurally and functionally unrelated substrates of P-gp, and its ATP-dependent outward-oriented transport, P-gp actively participates in intestinal secretion, blood… CONTINUE READING
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