Multidrug resistance‐associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate

@article{Homolya2003MultidrugRP,
  title={Multidrug resistance‐associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate},
  author={L{\'a}szl{\'o} Homolya and Andr{\'a}s V{\'a}radi and Bal{\'a}zs Sarkadi},
  journal={BioFactors},
  year={2003},
  volume={17}
}
Many endogenous or xenobiotic lipophilic substances are eliminated from the cells by the sequence of oxidation, conjugation to an anionic group (glutathione, glucuronate or sulfate) and transport across the plasma membrane into the extracellular space. The latter step is mediated by integral membrane glycoproteins belonging to the superfamily of ATP‐Binding Cassette (ABC) transporters. A subfamily, referred as ABCC, includes the famous/infamous cystic fibrosis transmembrane regulator (CFTR… 

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TLDR
The identification of the MRPs and the demonstration of a central role for ABC transporters, in general, in plant function not only provide fresh insights into the molecular basis of energy-dependent solute transport but also offer the prospect for manipulating and investigating many fundamental processes that have hitherto evaded analysis at the transport level.
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