Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials.

@article{Tegos2002MultidrugPI,
  title={Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials.},
  author={George P. Tegos and Frank R. Stermitz and Olga Lomovskaya and Kim Lewis},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 10},
  pages={3133-41}
}
Plant antimicrobials are not used as systemic antibiotics at present. The main reason for this is their low level of activity, especially against gram-negative bacteria. The reported MIC is often in the range of 100 to 1,000 micro g/ml, orders of magnitude higher than those of common broad-spectrum antibiotics from bacteria or fungi. Major plant pathogens belong to the gram-negative bacteria, which makes the low level of activity of plant antimicrobials against this group of microorganisms… CONTINUE READING
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