Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.

@article{Blair2014MultidrugEP,
  title={Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.},
  author={Jessica M A Blair and Grace E. Richmond and Laura J V Piddock},
  journal={Future microbiology},
  year={2014},
  volume={9 10},
  pages={1165-77}
}
Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting structurally varied molecules, including antibiotics, out of the bacterial cell. This efflux lowers the intracellular antibiotic concentration, allowing bacteria to survive at higher antibiotic concentrations. Overexpression of some efflux pumps can cause clinically relevant levels of antibiotic resistance in Gram-negative pathogens. This review discusses the role of efflux in resistance of clinical… CONTINUE READING
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