Multidrug efflux pumps and resistance: regulation and evolution.

  title={Multidrug efflux pumps and resistance: regulation and evolution.},
  author={Ian T. Paulsen},
  journal={Current opinion in microbiology},
  volume={6 5},
Multidrug transporters have long puzzled researchers because of their ability to extrude multiple structurally dissimilar toxic chemotherapeutic agents. They appear to be essentially ubiquitous with many microorganisms possessing large arsenals of predicted multidrug efflux transporters. Recent reports on the structures of multidrug efflux transporters and their cognate regulators have suggested that the basis of multidrug recognition is the presence of large flexible hydrophobic cavities… CONTINUE READING